Aggregation Of Sperm In A Spermogram – Causes, Treatment

Sperm aggregation is a pathological process characterized by gluing of male germ cells with subsequent formation of clots. For a spermogram of a healthy man, a similar phenomenon is not characteristic. The reason for contacting a medical specialist is the prolonged inability to conceive a child. If we consider this condition from the point of view of its danger, then the aggregation of spermatozoa leads to the formation of male infertility.

Decoding of spermogram indicators

The interpretation of the quantitative and qualitative composition of seminal fluid, in this case, may be ambiguous. Male germ cells can be fused with both mucus and other components.

Aggregation with cellular debris. The diagnosis of “aggregation with cell debris” implies the adhesion of spermatozoa, between which there are particles of dead cells. The leading cause of this condition is diseases of the male organs of the reproductive system of an inflammatory and non-inflammatory nature.

Aggregation with mucus. Often in a spermogram, aggregation of germ cells with mucus particles is observed. This condition is characterized by the appearance of small mucous lumps in seminal fluid. In the results of the spermogram, a decrease or increase in the amount of ejaculate can be observed.

In most cases, the cause of sperm aggregation with mucus is prostate vesiculitis in a chronic form. Prostate vesiculitis is characterized by inflammation of the prostate gland and seminal vesicles. Soldered sperm lose their ability to move, and, consequently, the potential for fertilization of the egg.

In addition to dead cells and mucus, during sperm aggregation, elements such as leukocytes, macrophages, and red blood cells can be observed in the spermogram. The appearance of each element indicates the development of a pathological condition in the male body.


At the time of diagnosis, sperm aggregation and agglutination should not be confused. The process of agglutination is characterized by gluing of spermatozoa to each other, and in the process of aggregation they are glued together with other biological structures.

Infectious and inflammatory diseases. Most often, the aggregation mechanism is based on an increase in the duration of the ejaculate liquefaction process. Infectious and inflammatory diseases of the testes, prostate gland and seminal ducts act as predisposing factors. In the presence of a chronic inflammatory process, an increase in the viscosity of seminal fluid is observed.

STI Very often, infectious diseases of the organs of the reproductive system that are transmitted through sexual transmission become the cause of aggregation of sex cells (see How to take an analysis for sexually transmitted infections).

Prostatitis, vesiculitis. If sperm aggregation with mucus particles was identified in the spermogram, then inflammation of the seminal vesicles (vesiculitis) may be the cause. As a rule, vesiculitis is formed against the background of a long-term inflammatory process of prostate tissue (prostatitis).

The danger of vesiculitis for the male body is that the result of this ailment is an increase in the density and viscosity of seminal fluid. Viscous and thick ejaculate is not able to serve as a favorable transport medium for male germ cells.

Accompanying illnesses. During the medical examination, in men with sperm aggregation, such concomitant diseases are often found:

    • paraproctitis;
    • orchoepididymitis;
    • cystitis;
    • pyelonephritis.
The infectious focus characteristic of each of the listed diseases can spread to the tissue of the prostate gland at any minute, causing inflammation in it. That is why timely diagnosis of chronic diseases plays an important role in maintaining the reproductive health of men.

State correction

If a man was diagnosed with “sperm aggregation with mucus”, then he will be recommended complex treatment of a underlying disease, such as vesiculitis or prostatitis.

When diagnosing only aggregation of germ cells with cell debris, basic therapy of this condition includes the intake of such groups of drugs:

    • multivitamin complexes containing minerals;
    • broad-spectrum antibacterial agents;
    • painkillers and antispasmodics;
    • hepatoprotectors.

The selection of antibacterial therapy is carried out individually, depending on the severity of the infectious process and the type of pathogen. After undergoing complex treatment, a man is recommended to make a control spermogram in order to determine the effectiveness of the received therapy.

If a man suffers from chronic diseases leading to the development of sperm aggregation, then he will need specialized treatment in a hospital. The result of timely therapy is the improvement of spermogram and the restoration of male fertility.